Calocurb Clinical: A Natural Tool for Appetite Control and Sustainable Weight Loss

At Integrative Weight Loss, our goal is to help patients lose weight safely, effectively, and sustainably — without relying on willpower alone. Many people trying to lose weight struggle with the same challenge: constant hunger and food cravings that make it difficult to stay consistent. These signals aren’t just in your mind; they’re biochemical.That’s why our program includes Calocurb Clinical, a plant-based supplement that works with your body’s own hormones to promote satiety, reduce appetite, and support smaller portions — naturally.

🌿 What Is Calocurb Clinical?

Calocurb Clinical is powered by Amarasate®, a patented extract of New Zealand bitter hops. This natural compound was developed through government-funded research exploring how bitter plant compounds can trigger the body’s satiety hormones.Unlike stimulants or caffeine-based suppressants, Calocurb gently activates your gut’s own “fullness receptors.” Patients often notice feeling fuller faster, fewer cravings, and improved control over snacking — within about an hour of taking it.

🔬 How It Works: The Science of Satiety

Each delayed-release capsule delivers Amarasate directly to the small intestine, where it stimulates bitter taste receptors (TAS2Rs) on enteroendocrine cells. This activation prompts the natural release of key fullness hormones:

• GLP-1 (Glucagon-Like Peptide-1) — slows stomach emptying, improves blood-sugar balance, and signals satiety to the brain.

• CCK (Cholecystokinin) — reduces appetite and encourages satisfaction with smaller meals. Together, these hormones help you eat less while feeling satisfied, supporting weight management without restriction or fatigue.

⚙️ Calocurb’s Role in the IWL Program

In our Integrative Weight Loss program, patients begin Calocurb Clinical immediately — one bottle is included to help you get started right away. This jump-starts appetite control while your peptide prescription (such as Tirzepatide) is being prepared. Many patients report noticing a calmer appetite, reduced cravings, and better control over portions even before beginning peptide therapy. Calocurb can also be used to:

• Maintain appetite balance after coming off GLP-1 medications

• Support perimenopausal weight changes

• Enhance intermittent fasting or time-restricted eating protocols

💊 Dosing and Tolerance

We recommend beginning with the Calocurb Starter Pack, which allows your body to adapt gradually to the increased hormone activation. A small number of patients experience a mild, temporary laxative effect in the first few days; this typically resolves within 24–72 hours.The Starter Pack contains 125 mg capsules for a gentle introduction before advancing to the full 250 mg Clinical strength. Our team will guide you on personalized dosing to match your metabolism and goals.

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📊 Clinical Research Highlights

• Human crossover trial: GLP-1 and CCK increased up to six-fold above baseline; calorie intake at a lunch + snack test meal was reduced by ~18%.• Fasting study (men): hunger reduced by ~80%, equating to a 20% overall reduction.• Fasting study (women): hunger reduced 100% and cravings reduced 120%, with 14% less rebound eating afterward.• Works within ~1 hour; effects last 4–6 hours.• No stimulants, caffeine, or artificial ingredients.

⚖️ How Calocurb Differs from GLP-1 Medications

Prescription GLP-1 analogs such as Semaglutide and Tirzepatide remain gold standards for medical weight loss, producing 15–25% reductions in body weight in clinical trials. Calocurb doesn’t replace these medications — it complements them. It’s a natural GLP-1 activator, promoting similar pathways without injections or side effects. It’s also an excellent bridge while starting or tapering off prescription therapy, helping maintain appetite balance throughout the transition.

🥗 Tips for Enhancing Satiety

Calocurb works best when paired with consistent nutrition habits:• Eat protein first: starting meals with protein stabilizes blood sugar and keeps you fuller longer.• Add fiber and healthy fats: vegetables, nuts, avocado, and olive oil promote long-lasting satisfaction.• Stay hydrated: begin the day with warm lemon water or apple-cider vinegar in water to support digestion.• Slow down: it takes about 20 minutes for fullness hormones to signal the brain — pausing helps you notice satisfaction sooner.• Keep regular meals: skipping meals can backfire, leading to rebound hunger.These simple steps amplify Calocurb’s natural appetite-balancing effects.

💛 Sustainable Weight-Loss Support

Calocurb Clinical is one of many evidence-based tools used in our Integrative Weight Loss program to help patients achieve lasting, confident control of their eating patterns. By supporting your body’s own satiety signals, it helps you eat less, feel satisfied, and maintain progress — all without harsh stimulants or restrictive dieting.I’m proud to offer this research-backed, natural option as part of our program and to see so many patients experience real improvements in appetite control and consistency.— Carrie Ballas, FNP-C

⚠️ A Note on Canola Oil

While we generally recommend limiting seed oils in the diet, the canola oil used in Calocurb serves a scientific function, not a nutritional one. It acts as an inert, stable carrier that disperses the Amarasate extract effectively in the gut — ensuring consistent activation of fullness hormones. This canola oil is cold-pressed, GMO-free, and glyphosate-free, selected purely for purity and performance.

📚 Resources & References

- Official Calocurb Website: https://www.calocurb.com- Plant & Food Research New Zealand – Amarasate®: https://plantandfood.co.nz/amarasate- Walker E et al. (2019). New Zealand bitter hops extract reduces hunger during a 24-h water-only fast. Nutrients 11(11):2754.- Walker E et al. (2024). Gastrointestinal delivery of bitter hops extract reduces appetite and food cravings in healthy adult women undergoing acute fasting. Obesity Pillars 11:100117.- Kim SH et al. (2021). Effect of the GLP-1 analogue liraglutide versus placebo on circulating proglucagon-derived peptides. Diabetes Obes Metab 23:489–498.